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Volume of white matter hyperintensities is an independent predictor of intelligence quotient and processing speed in children with sickle cell disease
Author(s) -
Land Veronica,
Hijmans Channa T.,
Ruiter Marieke,
Mutsaerts Henri J. M. M.,
Cnossen Marjon H.,
Engelen Marc,
Majoie Charles B. L. M.,
Nederveen Aart J.,
Grootenhuis Martha A.,
Fijnvandraat Karin
Publication year - 2015
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.13179
Subject(s) - neurocognitive , hyperintensity , intelligence quotient , cardiology , medicine , psychology , disease , wechsler adult intelligence scale , cognition , magnetic resonance imaging , psychiatry , radiology
Summary Sickle cell disease can be complicated by cerebral white matter hyperintensities ( WMH s), which are associated with diminished neurocognitive functioning. The influence of the total volume of WMH s on the degree of neurocognitive dysfunction has not yet been characterized. In our study of 38 patients (mean age 12·5 years) we demonstrated that a higher volume of WMH s was associated with lower full‐scale intelligence quotient ( IQ ), verbal IQ , Processing Speed Index and more fatigue. Our results suggest that volume of WMH s is an additional parameter to take into account when planning individual diagnostic and treatment options.