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Transient abnormal myelopoiesis ( TAM ) in a neonate without Down syndrome
Author(s) -
Bidet Audrey,
Dulucq Stéphanie,
Aladjidi Nathalie
Publication year - 2015
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.13166
Subject(s) - trisomy , pathology , buccal swab , nucleated red blood cell , medicine , immunophenotyping , fluorescence in situ hybridization , biology , andrology , immunology , fetus , microbiology and biotechnology , chromosome , pregnancy , genetics , antigen , gene
Transient abnormal myelopoiesis (TAM) also known as transient myeloproliferative disorder (TMD), a unique transient neonatal preleukaemic disorder characterized by clonal proliferation of megakaryoblasts, has been usually described to be associated with Down syndrome neonates. However, there are case reports of it occurring in neonates without Down phenotype, who are either mosaic for trisomy 21 or have trisomy 21 restricted to leukemic clone. This case report presents a case of TAM in a phenotypically normal neonate who presented in respiratory distress with features of tumour lysis syndrome (TLS) immediately after birth who was treated symptomatically and had spontaneous remission within three months.