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Microparticles as biomarkers of osteonecrosis of the hip in sickle cell disease
Author(s) -
Marsh Anne,
Schiffelers Raymond,
Kuypers Frans,
Larkin Sandra,
Gildengorin Ginny,
Solinge Wouter,
Hoppe Carolyn
Publication year - 2015
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.13110
Subject(s) - medicine , pathogenesis , femoral head , disease , sickle cell anemia , biomarker , pathology , oncology , surgery , biology , biochemistry
Summary Osteonecrosis of the femoral head ( ONFH ) is a common complication of sickle cell disease ( SCD ). To examine the association between microparticles and ONFH in SCD , we compared plasma microparticle levels in 20 patients with and without ONFH . Microparticles were quantified using nanoparticle tracking analysis and found to be 2·3‐fold higher in patients with ONFH compared to patients without ONFH , and 2·5‐fold higher than in healthy controls. These results suggest that microparticles may be a clinically useful biomarker of ONFH in SCD . Further investigations are needed to determine the functional relevance of microparticles in the pathogenesis of ONFH in SCD .