Premium
Histopathological features and their prognostic impact in nodular lymphocyte‐predominant Hodgkin lymphoma – a matched pair analysis from the German Hodgkin Study Group (GHSG)
Author(s) -
Hartmann Sylvia,
Eichenauer Dennis A.,
Plütschow Annette,
Mottok Anja,
Bob Roshanak,
Koch Karoline,
Bernd HeinzWolfram,
Cogliatti Sergio,
Hummel Michael,
Feller Alfred C.,
Ott German,
Möller Peter,
Rosenwald Andreas,
Stein Harald,
Hansmann MartinLeo,
Engert Andreas,
Klapper Wolfram
Publication year - 2014
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.12997
Subject(s) - lymphoma , cd15 , lymphocyte , epithelioid cell , pathology , medicine , reed–sternberg cell , lymph node , oncology , hodgkin lymphoma , immunohistochemistry , biology , cd34 , stem cell , genetics
Summary Nodular lymphocyte‐predominant Hodgkin lymphoma ( NLPHL ) is a rare lymphoma entity. We performed a matched‐pair analysis to evaluate the prognostic impact of several histopathological features in this distinct Hodgkin lymphoma subtype. Lymph node samples of NLPHL patients were tested for CD 15, IgD, phosphorylated STAT 6, ICOS and Epstein–Barr virus status of the malignant lymphocyte‐predominant cells as well as epithelioid cell clusters and activated T cells in the microenvironment. None of these features was associated with a particular clinical outcome. However, patients presenting with epithelioid cell clusters showed a non‐significant trend towards a lower relapse rate, justifying further evaluation of this marker.