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Class II human leucocyte antigen DRB 1*11 in hairy cell leukaemia patients with and without haemolytic uraemic syndrome
Author(s) -
Arons Evgeny,
Adams Sharon,
Venzon David J.,
Pastan Ira,
Kreitman Robert J.
Publication year - 2014
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.12956
Subject(s) - hematology , medicine , immunology
Summary Frequencies of human leucocyte antigens ( HLA ) were determined in 287 classic hairy cell leukaemia ( HCL ) patients. With respect to both population ( n = 287) and allele (2 n = 574) frequency respectively, the most common HLA class I and II antigens expressed were HLA ‐A*02 (49·1% and 28·6%), HLA ‐B*07 (21·3% and 11·1%), HLA ‐C*07 (46·7 and 28·2%), HLA ‐ DQB 1*03 (62·7% and 37·3%), HLA ‐ DRB 1*11 (30·0% and 16·0%) and HLA ‐ DRB 4*01 (45·3% and 29·6%). In comparing 6–14 databases of control Caucasians to 267 Caucasian HCL patients, only HLA ‐ DRB 1*11 was consistently over‐represented in HCL , 31·1% of patients vs. 17–19·9% of controls ( P = 0·0055 to <0·0001) and 16·5% of alleles vs. 6·5–12·3% of control alleles ( P = 0·022 to <0·0001). HLA ‐ DRB 1*11 is a known risk factor for acquired thrombotic microangiopathy. Anti‐ CD 22 recombinant immunotoxin BL 22 in HCL was associated with a 12% incidence of completely reversible grade 3–4 haemolytic uraemic syndrome ( HUS ), mainly during the second or third retreatment cycle. Of 49 HCL patients receiving ≥2 cycles of BL 22, 7 (14%) had HUS and HLA ‐ DRB 1*11 was expressed in 71% of 7 with HUS compared with only 21% of 42 without ( P = 0·015). These data suggest that DBR 1*11 may be a marker for increased susceptibility to HCL and, among HCL patients, could be a risk factor for BL 22‐induced HUS .