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Body size and multiple myeloma mortality: a pooled analysis of 20 prospective studies
Author(s) -
Teras Lauren R.,
Kitahara Cari M.,
Birmann Brenda M.,
Hartge Patricia A.,
Wang Sophia S.,
Robien Kim,
Patel Alpa V.,
Adami HansOlov,
Weiderpass Elisabete,
Giles Graham G.,
Singh Pramil N.,
Alavanja Michael,
Beane Freeman Laura E.,
Bernstein Leslie,
Buring Julie E.,
Colditz Graham A.,
Fraser Gary E.,
Gapstur Susan M.,
Gaziano J. Michael,
Giovannucci Edward,
Hofmann Jonathan N.,
Linet Martha S.,
Neta Gila,
Park Yikyung,
Peters Ulrike,
Rosenberg Philip S.,
Schairer Catherine,
Sesso Howard D.,
Stampfer Meir J.,
Visvanathan Kala,
White Emily,
Wolk Alicja,
ZeleniuchJacquotte Anne,
González Amy Berrington,
Purdue Mark P.
Publication year - 2014
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.12935
Subject(s) - medicine , hazard ratio , body mass index , prospective cohort study , waist , confidence interval , proportional hazards model , cohort , cohort study , multiple myeloma , cancer , obesity
Summary Multiple myeloma ( MM ) is a rare but highly fatal malignancy. High body weight is associated with this cancer, but several questions remain regarding the aetiological relevance of timing and location of body weight. To address these questions, we conducted a pooled analysis of MM mortality using 1·5 million participants (including 1388 MM deaths) from 20 prospective cohorts in the National Cancer Institute Cohort Consortium. Proportional hazards regression was used to calculate pooled multivariate hazard ratios ( HR s) and 95% confidence intervals ( CI s). Associations with elevated MM mortality were observed for higher early‐adult body mass index ( BMI ; HR = 1·22, 95% CI : 1·09–1·35 per 5 kg/m 2 ) and for higher cohort‐entry BMI ( HR 1·09, 95% CI : 1·03–1·16 per 5 kg/m 2 ) and waist circumference ( HR = 1·06, 95% CI : 1·02–1·10 per 5 cm). Women who were the heaviest, both in early adulthood ( BMI 25+) and at cohort entry ( BMI 30+) were at greater risk compared to those with BMI 18·5 ≤ 25 at both time points ( HR = 1·95, 95% CI : 1·33–2·86). Waist‐to‐hip ratio and height were not associated with MM mortality. These observations suggest that overall, and possibly also central, obesity influence myeloma mortality, and women have the highest risk of death from this cancer if they remain heavy throughout adulthood.