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Age disparities in survival from lymphoma and myeloma: a comparison between US and E ngland
Author(s) -
Pulte Dianne,
Redaniel Maria T.,
Lowry Lisa,
Bird Jenny,
Jeffreys Mona
Publication year - 2014
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.12837
Subject(s) - medicine , lymphoma , multiple myeloma , hazard ratio , hodgkin lymphoma , relative survival , proportional hazards model , population , cancer , cancer registry , confidence interval , environmental health
Summary Population‐level survival in older patients with lymphoma is significantly lower than in younger patients. In this study, data were obtained from cancer registries in E ngland and the U nited S tates ( US ) for patients diagnosed with H odgkin lymphoma ( HL ), non‐ H odgkin lymphoma ( NHL ) and myeloma. Five‐year relative survival was calculated using period analysis. Generalised linear models were used to determine excess hazard ratios ( EHR ) for older compared to younger patients. Five‐year relative survival was lower for older patients diagnosed with HL , NHL and myeloma in both countries. The greatest age‐related survival inequality was observed for patients with HL : in 2006–10 the EHR comparing patients aged 75 + years with those aged 15–24 years was 14·02 in the US and 15·69 in E ngland. For NHL , the EHR was 1·91 in the US and 3·81 in E ngland. For myeloma, comparing patients aged 75 + years with those aged 25–44 years, the EHR was 2·79 in the US and 3·60 in E ngland. Survival of patients with lymphoma is lower for older patients in both the US and E ngland but the discrepancy is less in the US . Physicians should be encouraged to evaluate patients' frailty and co‐morbidities as well as their age when considering treatment options for patients with lymphoma and myeloma.