Premium
Risk factor analysis of non‐Hodgkin lymphoma‐associated haemophagocytic syndromes: a multicentre study
Author(s) -
Sano Hirozumi,
Kobayashi Ryoji,
Tanaka Junji,
Hashino Satoshi,
Ota Shuichi,
Torimoto Yoshihiro,
Kakinoki Yasutaka,
Yamamoto Satoshi,
Kurosawa Mitsutoshi,
Hatakeyama Naoki,
Haseyama Yoshihito,
Sakai Hajime,
Sato Kazuya,
Fukuhara Takashi
Publication year - 2014
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.12823
Subject(s) - lymphoma , medicine , incidence (geometry) , t cell lymphoma , cumulative incidence , gastroenterology , risk factor , transplantation , physics , optics
Summary Haemophagocytic syndrome is often associated with malignant lymphoma; however, few studies have examined lymphoma‐associated haemophagocytic syndrome ( LAHS ). A total of 1239 patients with non‐Hodgkin lymphoma were analysed at 12 institutions in Hokkaido prefecture between January 2007 and December 2011 to assess the incidence, prognosis and risk factors of LAHS . The cumulative incidence rate of LAHS was 2·8% (35/1239). Overall survival ( OS ) in patients with LAHS was significantly inferior to those without LAHS (3‐year OS : 35·6 vs. 59·0% respectively, P < 0·0001). The cumulative incidence of LAHS was higher in patients with T/Natural Killer ( NK )‐cell lymphoma than in those with B‐cell lymphoma (8·2 vs. 1·8% respectively, P < 0·0001). The characteristics of patients with and without early death (within the first 120 d after developing LAHS ) were subsequently compared to evaluate the prognostic factor of LAHS . The results obtained showed that the rate of early death after developing LAHS was higher in patients with T/ NK ‐cell lymphoma than in those with B‐cell lymphoma (62·5 vs. 10·5%, P = 0·0033). In conclusion, the complication and mortality rates of LAHS were higher in patients with T/ NK ‐cell lymphoma after they developed LAHS than in those with B‐cell lymphoma.