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Incidence of marginal zone lymphoma in the United States, 2001–2009 with a focus on primary anatomic site
Author(s) -
Khalil Mohammad O.,
Morton Lindsay M.,
Devesa Susan S.,
Check David P.,
Curtis Rochelle E.,
Weisenburger Dennis D.,
Dores Graça M.
Publication year - 2014
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.12730
Subject(s) - incidence (geometry) , medicine , focus (optics) , lymphoma , pathology , geometry , physics , optics , mathematics
Summary The aetiology of marginal zone lymphoma ( MZL ) is purported to differ by anatomic site. While this is supported by clinical series of single MZL sites, no population‐based study has comprehensively assessed incidence patterns across sites. To gain insight into disease aetiology, we assessed MZL incidence by site using data from 18 U.S. Surveillance, Epidemiology and End Results ( SEER ) Program population‐based registries. We calculated age‐adjusted incidence rates ( IR s) by sex, race, and calendar year. During 2001–2009, 4,081 ( IR = 5·7/1,000,000 person‐years) and 8,821 ( IR = 12·3) individuals were diagnosed with nodal MZL and extranodal MZL , respectively. The most common extranodal sites were stomach ( IR = 3·8), spleen ( IR = 1·6), eye/adnexa ( IR = 1·4), and lung, skin, and salivary glands ( IR s = 0·9–1·0). We observed distinct age‐specific patterns by MZL site, with IR s increasing steeply at younger ages and less prominently after mid‐life at several sites, except skin. Gender and racial/ethnic disparities were also apparent across sites. Between 2001–2005 and 2006–2009, MZL IR s decreased significantly for gastric (−15%) and soft tissue (−28%) sites, whereas IR s increased significantly for lung (18%), skin (43%), and kidney/renal pelvis (116%). In combination, our findings support the contention that MZL is characterized by aetiological heterogeneity across sites and susceptibility is probably influenced by intrinsic characteristics and environmental exposures.