z-logo
Premium
Hodgkin lymphoma patients in first remission: routine positron emission tomography/computerized tomography imaging is not superior to clinical follow‐up for patients with no residual mass
Author(s) -
Dann Eldad J.,
Berkahn Leanne,
Mashiach Tatiana,
Frumer Michael,
Agur Ariel,
McDiarmid Bridgett,
BarShalom Rachel,
Paltiel Ora,
Goldschmidt Neta
Publication year - 2014
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.12687
Subject(s) - medicine , positron emission tomography , lymphoma , retrospective cohort study , radiology , chemotherapy , nuclear medicine
Summary There is no consensus regarding optimal follow‐up mode for Hodgkin lymphoma ( HL ) patients that achieve complete remission following chemotherapy or combined chemo‐ and radiation therapy. Several studies demonstrated high sensitivity of positron emission tomography/computerized tomography ( PET / CT ) in detecting disease progression; however, these techniques are currently not recommended for routine follow‐up. This retrospective study conducted in two Israeli ( N  = 291) and one New Zealand academic centres ( N  = 77), compared a group of HL patients, followed‐up with routine imaging every 6 months during the first 2 years after achieving remission, once in the third year, with additional dedicated studies performed due to symptoms or physical findings (Group I) to a group of patients without residual masses who underwent clinically‐based surveillance with dedicated imaging upon relapse suspicion (Group II ). Five‐year overall survival ( OS ) was 94% and median time to relapse was 8·6 months for both modes. Relapse rates in Groups I and II were 13% and 9%, respectively. During the first 3 years of follow‐up, 47·5 and 4·7 studies were performed per detected relapse in Groups I and II , respectively. The current study demonstrated no benefit in either progression‐free survival ( PFS ) or OS in HL patients followed by routine imaging versus clinical follow‐up. The cost was 10 times higher for routine imaging.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here