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Community‐acquired infections associated with increased risk of lymphoplasmacytic lymphoma/Waldenström macroglobulinaemia
Author(s) -
McShane Charlene M.,
Murray Liam J.,
Engels Eric A.,
Anderson Lesley A.
Publication year - 2014
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.12671
Subject(s) - lymphoplasmacytic lymphoma , medicine , waldenstrom macroglobulinemia , epidemiology , immunology , lymphoma
Summary Emerging evidence supports the role of immune stimulation in the development of lymphoplasmacytic lymphoma/Waldenström Macroglobulinaemia ( LPL / WM ). Using the population‐based Surveillance, Epidemiology End Results‐Medicare database we investigated the exposure to 14 common community‐acquired infections and subsequent risk of LPL / WM in 693 LPL / WM cases and 200 000 controls. Respiratory tract infections, bronchitis [odds ratio ( OR ) 1·56], pharyngitis ( OR 1·43), pneumonia ( OR 1·42) and sinusitis ( OR 1·33) and skin infection, herpes zoster ( OR 1·51) were all significantly associated with subsequent increased risk of LPL / WM . For each of these infections, the findings remained significantly elevated following the exclusion of more than 6 years of Medicare claims data prior to LPL / WM diagnosis. Our findings may support a role for infections in the development of LPL / WM or could reflect an underlying immune disturbance that is present several years prior to diagnosis and thereby part of the natural history of disease progression.