Erythroid‐extrinsic regulation of normal erythropoiesis by retinoic acid receptors | Zendy

Dewamitta Sita R. | Zendy; Joseph Chacko | Zendy; Purton Louise E. | Zendy; Walkley Carl R. | Zendy

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Erythroid‐extrinsic regulation of normal erythropoiesis by retinoic acid receptors

Author(s) -

Dewamitta Sita R.,

Joseph Chacko,

Purton Louise E.,

Walkley Carl R.

Publication year - 2014

Publication title -

british journal of haematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.907

H-Index - 186

eISSN - 1365-2141

pISSN - 0007-1048

DOI - 10.1111/bjh.12578

Subject(s) - erythropoiesis , retinoic acid , receptor , tretinoin , endocrinology , hematology , microbiology and biotechnology , biology , medicine , immunology , anemia , genetics , gene

Summary Vitamin A and its derivatives (retinoids) are important regulators of haematopoiesis, acting via retinoic acid receptors ( RAR s). Epidemiological studies indicated an association of vitamin A deficiency with anaemia in humans. To define the requirements of RAR s in erythropoiesis, we evaluated erythroid parameters in RAR germ‐line deficient and conditional knock out mice with erythroid specific deletion of RAR s. Adult RAR γ −/ − mice were anaemic, however, Epor‐ Cre Rara fl/fl , Epor ‐Cre Rarg fl/fl and Epor ‐Cre Rara fl/fl g fl/fl mice were normal, indicating a lack of an erythroid intrinsic RAR function. Therefore, erythroid‐specific RAR function is dispensable for erythropoiesis and RAR γ plays an erythroid extrinsic role in erythropoiesis.

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