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Erythroid‐extrinsic regulation of normal erythropoiesis by retinoic acid receptors
Author(s) -
Dewamitta Sita R.,
Joseph Chacko,
Purton Louise E.,
Walkley Carl R.
Publication year - 2014
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.12578
Subject(s) - erythropoiesis , retinoic acid , receptor , tretinoin , endocrinology , hematology , microbiology and biotechnology , biology , medicine , immunology , anemia , genetics , gene
Summary Vitamin A and its derivatives (retinoids) are important regulators of haematopoiesis, acting via retinoic acid receptors ( RAR s). Epidemiological studies indicated an association of vitamin A deficiency with anaemia in humans. To define the requirements of RAR s in erythropoiesis, we evaluated erythroid parameters in RAR germ‐line deficient and conditional knock out mice with erythroid specific deletion of RAR s. Adult RAR γ −/ − mice were anaemic, however, Epor‐ Cre Rara fl/fl , Epor ‐Cre Rarg fl/fl and Epor ‐Cre Rara fl/fl g fl/fl mice were normal, indicating a lack of an erythroid intrinsic RAR function. Therefore, erythroid‐specific RAR function is dispensable for erythropoiesis and RAR γ plays an erythroid extrinsic role in erythropoiesis.