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Changes in angiogenesis and hypoxia‐inducible factor‐1α protein expression in relapsed/refractory indolent non‐ H odgkin lymphomas
Author(s) -
Minoia Carla,
Quero Carmela,
Asselti Mariaconsilia,
Galise Ida,
Marzano Alessia L.,
Iacobazzi Angela,
Rana Antonio,
Merchionne Francesca,
Serratì Simona,
De Tullio Giacoma,
Quintana Giovanni,
Casiello Michela,
Maiorano Eugenio,
Simone Giovanni,
Zito Francesco A.,
Iacopino Pasquale,
Guarini Attilio
Publication year - 2013
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.12560
Subject(s) - angiogenesis , immunohistochemistry , medicine , pathology , hypoxia (environmental) , pathogenesis , cancer research , hypoxia inducible factors , tumor progression , hif1a , biopsy , biology , cancer , gene , chemistry , biochemistry , organic chemistry , oxygen
Summary Angiogenesis is involved in the pathogenesis and progression of non‐ H odgkin lymphomas ( NHL ), and hypoxia‐inducible factor‐1α ( HIF ‐1α, also termed HIF 1 A ) might contribute to this process. Currently, there is no direct evidence that the clinical progression of indolent NHL is associated with angiogenesis, and the expression of HIF ‐1α at recurrence is unknown. Matched lymph node biopsies at diagnosis and recurrence of relapsed/refractory indolent NHL patients were analysed by immunohistochemical and morphometric analysis. We observed an increased vascular network and HIF ‐1α protein expression in the second biopsy, providing direct evidence that angiogenesis is an essential process for disease progression.