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Non‐irradiated female survivors of childhood acute lymphoblastic leukaemia are at risk of long‐term increases in weight and body mass index
Author(s) -
Harper Robert L. C.,
Breene Richard A. L.,
Gattens Michael,
Williams Rachel M.,
Murray Matthew J.
Publication year - 2013
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.12552
Subject(s) - medicine , body mass index , pediatrics , body weight , weight gain
Summary We report long‐term, including final height, auxological data from our retrospective study of non‐irradiated survivors of childhood acute lymphoblastic leukaemia ( ALL ). Body mass index ( BMI ) standard deviation score ( SDS ) increases in females, due to increased weight‐ SDS , persisted to final height, with probable adverse long‐term health outcomes. In contrast, males demonstrated increased BMI ‐ SDS in follow‐up, due to reduced height‐ SDS , not increased weight‐ SDS , but such changes had resolved by final height. Childhood ALL survivors, particularly females, are therefore at potential increased risk of developing the metabolic syndrome during follow‐up. We recommend that strategies to minimize weight gain should be implemented during ALL treatment.