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Subcortical and cerebellar volumetric deficits in paediatric sickle cell anaemia
Author(s) -
Kawadler Jamie M.,
Clayden Jonathan D.,
Kirkham Fenella J.,
Cox Timothy C.,
Saunders Dawn E.,
Clark Chris A.
Publication year - 2013
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.12496
Subject(s) - putamen , white matter , grey matter , magnetic resonance imaging , thalamus , medicine , cerebellum , abnormality , caudate nucleus , pathology , brain size , amygdala , hippocampus , neuroscience , psychology , radiology , psychiatry
Summary Sickle cell anaemia ( SCA ) is associated with silent cerebral infarction ( SCI ), affecting white and cortical grey matter, but there are few data on subcortical volumes. We analysed retrospective magnetic resonance imaging ( MRI ) data in 26 SCA patients and 20 controls, comparing mean subcortical volumes between three groups: controls, SCA with SCI ( n = 13) and SCA without visible abnormality ( n = 13). Specific volumetric differences were found in the hippocampus, amygdala, pallidum, caudate, putamen, thalamus, and cerebellum. This is the first study to demonstrate subcortical volume change in SCA , with the most severe volumetric deficits occurring in children with SCI seen on MRI .