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Hypomethylation of the CTGF gene locus is a common feature of paediatric pre‐ B acute lymphoblastic leukaemia
Author(s) -
Welch Mathew D.,
Greene Wayne K.,
Kees Ursula R.
Publication year - 2013
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.12417
Subject(s) - ctgf , locus (genetics) , growth factor , biology , dna methylation , cancer research , histone , gene , gene expression , genetics , receptor
Summary The connective tissue growth factor gene ( CTGF ) is aberrantly expressed in 75% of precursor B‐cell acute lymphoblastic leukaemias (pre‐B ALL ) and is associated with poor outcome. We identified consistent hypomethylation of the CTGF locus in primary pre‐B ALL specimens regardless of CTGF expression. By contrast, primary T‐cell ALL specimens, which do not express CTGF , exhibited distinctive patterns of hypermethylation. Furthermore, we confirmed that global changes in DNA methylation and histone acetylation can both functionally modulate CTGF expression in pre‐B ALL cell lines. These data suggest that hypomethylation of the CTGF locus is an essential prerequisite for aberrant CTGF expression in pre‐B ALL .