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No significant prognostic value of normal precursor B ‐cell regeneration in paediatric acute myeloid leukaemia after induction treatment
Author(s) -
Bras Anne E.,
HeuvelEibrink Marry M.,
SluijsGelling Alita J.,
Coenen Eva A.,
Wind Henk,
Zwaan C. Michel,
te Marvelde Jeroen G.,
Burg Mirjam,
Gibson Brenda,
Rijneveld Anita W.,
Haas Valérie,
Dongen Jacques J. M.,
Velden Vincent H. J.
Publication year - 2013
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.12329
Subject(s) - medicine , regeneration (biology) , minimal residual disease , myeloid leukaemia , myeloid , bone marrow , induction chemotherapy , chemotherapy , precursor cell , oncology , immunology , cell , biology , genetics , microbiology and biotechnology
Summary B‐cell precursors ( BCP ) regeneration in bone marrow ( BM ) after induction chemotherapy is prognostic for good treatment response in adult acute myeloid leukaemia ( AML ). We detected BCP regeneration in 81% of 59 paediatric AML patients at first complete remission; this compared to 46% in an adult study. BCP regeneration did not correlate with outcome or minimal residual disease levels. In 36 healthy BM controls, BCP levels were significantly higher in children as compared to adults. Therefore, BCP regeneration does not reflect good response to treatment in paediatric AML , possibly due to the relatively high base‐line levels of BCP in children.