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Systemic Amyloidosis in E ngland: an epidemiological study
Author(s) -
Pinney Jennifer H.,
Smith Colette J.,
Taube Jessi B.,
Lachmann Helen J.,
Venner Christopher P.,
Gibbs Simon D. J.,
Dungu Jason,
Banypersad Sanjay M.,
Wechalekar Ashutosh D.,
Whelan Carol J.,
Hawkins Philip N.,
Gillmore Julian D.
Publication year - 2013
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.12286
Subject(s) - amyloidosis , death certificate , incidence (geometry) , medicine , epidemiology , population , al amyloidosis , cause of death , pediatrics , disease , immunology , environmental health , immunoglobulin light chain , physics , antibody , optics
Summary Epidemiological studies of systemic amyloidosis are scarce and the burden of disease in E ngland has not previously been estimated. In 1999, the N ational H ealth S ervice commissioned the N ational A myloidosis C entre ( NAC ) to provide a national clinical service for all patients with amyloidosis. Data for all individuals referred to the NAC is held on a comprehensive central database, and these were compared with E nglish death certificate data for amyloidosis from 2000 to 2008, obtained from the O ffice of N ational S tatistics. Amyloidosis was stated on death certificates of 2543 individuals, representing 0·58/1000 recorded deaths. During the same period, 1143 amyloidosis patients followed at the NAC died, 903 (79%) of whom had amyloidosis recorded on their death certificates. The estimated minimum incidence of systemic amyloidosis in the E nglish population in 2008, based on new referrals to the NAC , was 0·4/100 000 population. The incidence peaked at age 60–79 years. Systemic AL amyloidosis was the most common type with an estimated minimum incidence of 0·3/100 000 population. Although there are various limitations to this study, the available data suggest the incidence of systemic amyloidosis in E ngland exceeds 0·8/100 000 of the population.