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Modern management of lymphocyte predominant H odgkin lymphoma
Author(s) -
Xing Katharine H.,
Savage Kerry J.
Publication year - 2013
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.12244
Subject(s) - cd15 , cd30 , lymphoma , cd20 , medicine , lymphocyte , pathological , stage (stratigraphy) , hodgkin lymphoma , pathology , immunology , biology , cd34 , paleontology , genetics , stem cell
Summary Nodular lymphocyte predominant H odgkin lymphoma ( NLPHL ) represents 5% of all Hodgkin lymphoma and has distinct clinico‐pathological features. It is typified by the presence of lymphocyte predominant cells, which are CD 20 + , CD 15 − and CD 30 − and are found scattered amongst small B ‐lymphocytes arranged in a nodular pattern. Patients typically are males presenting with localized, peripheral lymphadenopathy. Despite frequent and often late or multiple relapses the prognosis is favourable. Deaths due to NLPHL are uncommon, but secondary malignancies and other treatment toxicities contribute appreciably to overall mortality. Secondary aggressive non‐Hodgkin lymphoma can occur in approximately 7–14% of cases of NLPHL . Given this diseases' rarity, the optimal management is unclear and opinions differ as to whether treatment paradigms should be similar to or differ from those for classical Hodgkin lymphoma. This review provides an overview of the existing literature describing of the outcome and treatment approaches for limited and advanced stage NLPHL .