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Micro RNA s and lymphomagenesis: a functional review
Author(s) -
Lawrie Charles H.
Publication year - 2013
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.12157
Subject(s) - microrna , biology , lymphoma , cancer , gene , cancer research , computational biology , genetics , immunology
Summary The relatively recent discovery of micro RNA s (mi RNA s) has exposed an extra layer of gene expression regulation that affects many physiological and pathological processes of biology. Dysregulation of mi RNA s is a ubiquitous feature of cancer in general, including lymphomas. The identity of these aberrantly‐expressed mi RNA s has been thoroughly investigated in all but a few types of lymphomas, however their functional role in lymphomagenesis much less so. This review focuses on those mi RNA s that have an experimentally confirmed functional role in the pathogenesis of the most frequent forms of lymphoma. In particular, the MIR 15A/16‐1 cluster, MIR 21, MIR 155, MIR 17 HG ( MIR 17‐92 cluster) , MIR 34A and MIR 125B, which have in vivo animal model evidence for their involvement in lymphomagenesis, are highlighted.