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New ways to separate Graft‐ versus ‐Host Disease and Graft‐ versus ‐Tumour effects after allogeneic haematopoietic stem cell transplantation
Author(s) -
Kotsiou Eleni,
Davies Jeff K.
Publication year - 2013
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.12115
Subject(s) - transplantation , stem cell , haematopoiesis , immunology , graft versus host disease , immune system , disease , medicine , effector , graft rejection , hematopoietic stem cell transplantation , biology , genetics
Summary A major challenge to transplant immunologists and physicians remains the separation of harmful graft‐ versus ‐host disease ( G v HD ) and beneficial graft‐ versus ‐tumour ( G v T ) effects after allogeneic haematopoietic stem cell transplantation. Recent advances in our understanding of the allogeneic immune response provide potential new opportunities to achieve this goal. Three potential new approaches that capitalize on this new knowledge are considered in depth; the manipulation of organ‐specific cytokines and other pro‐inflammatory signals, the selective manipulation of donor effector T cell migration, and the development of cell‐mediated immunosuppressive strategies using donor‐derived regulatory T cells. These new approaches could provide strategies for local control of allogeneic immune responses, a new paradigm to separate G v HD and G v T effects. Although these strategies are currently in their infancy and have challenges to successful translation to clinical practice, all have exciting potential for the future.