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Challenges of alloimmunization in patients with haemoglobinopathies
Author(s) -
Chou Stella T.,
Liem Robert I.,
Thompson Alexis A.
Publication year - 2012
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.12061
Subject(s) - medicine , intensive care medicine , disease , thalassemia , blood transfusion , pediatrics , immunology
Summary Red blood cell ( RBC ) transfusions can be life‐sustaining in chronic inherited anaemias, such as thalassaemia, and the indications for blood transfusions in patients with sickle cell disease continue to expand. Complications of transfusions, such as allosensitization, can create significant medical challenges in the management of patients with haemoglobinopathies. This review summarizes key findings from the medical literature related to alloimmunization in haemoglobinopathies and examines potential measures to mitigate these risks. Areas where future studies are needed are also addressed.