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Nodular lymphocyte predominant H odgkin lymphoma in children and adolescents – a comprehensive review of biology, clinical course and treatment options
Author(s) -
Shankar Ananth,
Daw Stephen
Publication year - 2012
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.12055
Subject(s) - radiation therapy , lymphoma , medicine , disease , hodgkin lymphoma , lymphocyte , chemotherapy , stage (stratigraphy) , oncology , immunology , pathology , biology , paleontology
Summary Nodular lymphocyte predominant H odgkin lymphoma (n LPHL ) is a unique variant of H odgkin lymphoma with an overall good prognosis. It is conspicuously different from classical H odgkin lymphoma (c HL ) and is now recognized as distinctive form of B cell lymphoma. Although it has an indolent clinical course, it has a propensity for multiple and often late relapses. Although the majority of children present with early stage disease and without B symptoms, treatment strategy has, until recently, been identical to that used for c HL . This approach is excessively toxic as it predisposes these children and adolescents to serious late effects including end organ damage to heart, gonads, lungs, thyroid and second malignant neoplasms. The aim of this article is to review the published literature on the treatment outcomes of n LPHL in affected children and adolescents, and discuss the options for treatment including surgery, chemotherapy, radiotherapy and targeted anti‐ CD 20 antibody therapy.