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High dose vitamin D therapy for chronic pain in children and adolescents with sickle cell disease: results of a randomized double blind pilot study
Author(s) -
Osunkwo Ifeyinwa,
Ziegler Thomas R.,
Alvarez Jessica,
McCracken Courtney,
Cherry Korin,
Osunkwo Chinyere E.,
OforiAcquah Solomon F.,
Ghosh Samit,
Ogunbobode Adeolu,
Rhodes Jim,
Eckman James R.,
Dampier Carlton,
Tangpricha Vin
Publication year - 2012
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.12019
Subject(s) - medicine , vitamin d and neurology , cholecalciferol , placebo , vitamin d deficiency , quality of life (healthcare) , vitamin , prospective cohort study , randomized controlled trial , pilot trial , disease , clinical trial , gastroenterology , physical therapy , pathology , alternative medicine , nursing
Summary We report results of a pilot study of high‐dose vitamin D in sickle cell disease ( SCD ). Subjects were given a 6‐week course of oral high‐dose cholecalciferol (4000–100 000 IU per week) or placebo and monitored prospectively for a period of six months. Vitamin D insufficiency and deficiency was present at baseline in 82·5% and 52·5% of subjects, respectively. Subjects who received high‐dose vitamin D achieved higher serum 25‐hydroxyvitamin D , experienced fewer pain days per week, and had higher physical activity quality‐of‐life scores. These findings suggest a potential benefit of vitamin D in reducing the number of pain days in SCD . Larger prospective studies with longer duration are needed to confirm these effects.