Premium
The interferon‐γ‐induced protein 10/CXCR3 axis is associated with human herpesvirus‐6 reactivation and the development of sequelae in drug reaction with eosinophilia and systemic symptoms *
Author(s) -
Yang C.W.,
Cho Y.T.,
Hsieh Y.C.,
Hsu S.H.,
Chen K.L.,
Chu C.Y.
Publication year - 2020
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.18942
Subject(s) - cxcr3 , medicine , immunology , cxcl10 , cd8 , peripheral blood mononuclear cell , ccr4 , eosinophilia , pathology , immune system , biology , chemokine , biochemistry , chemokine receptor , in vitro
Summary Background Drug reaction with eosinophilia and systemic symptoms ( DRESS ) is a condition caused by a drug‐induced immune response. Previous reports have found that CXCL 10, also known as interferon‐γ‐induced protein ( IP )‐10, may participate in the pathogenesis of cutaneous adverse drug reactions. However, the exact role of IP ‐10 in DRESS and Stevens–Johnson syndrome ( SJS )/toxic epidermal necrolysis ( TEN ) has remained unknown. Objectives This comparative prospective cohort study aimed to ascertain the roles of the IP ‐10/ CXCR 3 axis in DRESS and SJS / TEN . Methods Plasma IP ‐10 levels were analysed, and univariate analyses were conducted to assess the relationship between IP ‐10, human herpesvirus ( HHV )‐6 reactivation and the development of long‐term sequelae. We also performed immunohistochemical staining using skin specimens and flow cytometry to determine the expression of CXCR 3 in peripheral blood mononuclear cells ( PBMC s). Results Significantly higher plasma IP ‐10 levels were observed in patients with DRESS with long‐term sequelae (effect size 0·81) and also in those with HHV ‐6 reactivation (effect size 0·83). By immunohistochemistry, more abundant IP ‐10 + and CXCR 3 + cells were demonstrated in the skin lesions of patients with DRESS with HHV ‐6 reactivation. The percentages of CLA + CXCR 3 + CD 4 + cells and CLA + CXCR 3 + CD 8 + cells were also higher in the PBMC s of HHV ‐6‐reactivated patients with DRESS than in those of patients with SJS / TEN . Conclusions Higher plasma IP ‐10 levels are associated with the development of long‐term sequelae in DRESS . Higher IP ‐10/ CXCR 3 expression in skin and more abundant CLA + CXCR 3 + CD 4 + cells and CLA + CXCR 3 + CD 8 + cells were observed in patients with DRESS with HHV ‐6 reactivation. The IP ‐10/ CXCR 3 axis is associated with HHV ‐6 reactivation and development of long‐term sequelae in DRESS .What is already known about this topic?Elevated levels of interferon‐γ‐induced protein‐10 (IP‐10) have been observed in patients with drug reaction with eosinophilia and systemic symptoms (DRESS) and Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). Patients with DRESS tend to develop long‐term autoimmune sequelae, including type 1 diabetes and autoimmune thyroiditis. IP‐10 has been associated with these autoimmune diseases in previous studies.What does this study add?The patients with DRESS with HHV‐6 reactivation exhibited higher levels of IP‐10 in the plasma and skin than the patients with DRESS without HHV‐6 reactivation and the patients with SJS/TEN. Patients with DRESS with higher plasma IP‐10 levels tended to develop sequelae during long‐term follow‐up.What is the translational message?IP‐10 is a useful biomarker to predict the development of long‐term sequelae in patients with DRESS.Linked Comment: Belloón and Kardaun. Br J Dermatol 2020; 183 :804–805.