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Defining lesional, perilesional and unaffected skin in hidradenitis suppurativa: proposed recommendations for clinical trials and translational research studies
Author(s) -
Frew J.W.,
Navrazhina K.,
Byrd A.S.,
Garg A.,
Ingram J.R.,
Kirby J.S.,
Lowes M.A.,
Naik H.,
Piguet V.,
Prens E.P.
Publication year - 2019
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.18309
Subject(s) - hidradenitis suppurativa , medicine , dermatology , clinical trial , translational research , surgery , pathology , disease
Hidradenitis suppurativa (HS) is a chronic, recurring inflammatory skin condition for which the pathogenesis is not completely elucidated1 . With the increase in HS-related research comes the need to enhance reproducibility, quality and accuracy of scientific methods. Unlike other inflammatory dermatoses such as psoriasis or atopic dermatitis, HS lesions are morphologically diverse and include nodules, abscesses, tunnels and fibrosis in various permutations and combinations admixed in the same anatomical region1 . This makes general definitions as 'lesional' and 'non-lesional' insufficient for HS-related investigations. A definition for non-lesional skin is lacking. This article is protected by copyright. All rights reserved.