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Assessing effectiveness in acne clinical trials: steps towards a core outcome measure set
Author(s) -
Thiboutot D.M.,
Layton A.M.,
Chren M.M.,
Eady E.A.,
Tan J.
Publication year - 2019
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.18011
Subject(s) - acne , clinical trial , medicine , set (abstract data type) , outcome (game theory) , measure (data warehouse) , core (optical fiber) , medline , computer science , dermatology , data mining , mathematics , biology , telecommunications , mathematical economics , programming language , biochemistry
Summary Background Acne ranks second to dermatitis in terms of global burden of skin disease. As such, it is essential that data on treatment efficacy are generated in a way that maximizes the opportunity for comparison among treatments. Interest in developing core outcome sets for use in clinical trials to standardize data collection in skin disease is surging. Objectives The goal of this review is to provide an update on the efforts underway, challenges encountered and future directions in the development of an acne core outcome measure set for use in clinical trials. Methods The activities of the Acne Core Outcomes Research Network ( ACORN ) are presented in the context of currently acceptable methodologies for core outcome set development. Conclusions Emphasis is placed on following a rigorous methodology, involving patients and recognizing a role for emerging technologies.