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Image Gallery: Reproduction of the Auspitz sign by videodermatoscopy, confocal microscopy and horizontal histopathology
Author(s) -
Nasca M.R.,
Lacarrubba F.,
Caltabiano R.,
Micali G.
Publication year - 2019
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.17649
Subject(s) - histopathology , sign (mathematics) , confocal microscopy , reproduction , microscopy , pathology , biology , anatomy , medicine , mathematics , microbiology and biotechnology , mathematical analysis , ecology
DEAR EDITOR, In 20 psoriatic plaques showing positive Auspitz sign (a), videodermatoscopy detected regularly distributed dilated capillaries with a ‘bushy’ aspect (b; original magnification 9 150). Reflectance confocal microscopy revealed, at superficial layers after a few horizontal scans, rounded dark areas with central structures containing bright elements in real-time motion, interspersed among epidermal keratinocytes arranged in a honeycomb pattern (c). At horizontal histopathology sections of the same fields, the dark areas corresponded to the tips of numerous, enlarged, superficialized dermal papillae containing dilated/tortuous capillary loops (d; haematoxylin and eosin, original magnification 9 100), resulting from papillomatosis with thinning of the suprapapillary plate. Our study demonstrated overlapping morphological changes underlying the clinical Auspitz sign, in horizontal histopathology sections, videodermatoscopy and reflectance confocal microscopy imaging.