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Stratum corneum and systemic biomarkers in infantile AD
Author(s) -
McAleer M.A.,
Jakasa I.,
Hurault G.,
Sarvari P.,
McLean W.H.I.,
Tanaka R.J.,
Kezic S.,
Irvine A.D.
Publication year - 2019
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.17554
Subject(s) - seriousness , medicine , disease , stratum corneum , pediatrics , physiology , pathology , law , political science
Summary Atopic Dematitis (AD), also known as eczema, is a common inflammatory skin disease which usually appears during the early stages of life. It is estimated that approximately 15 million people in the UK are currently living with AD, affecting up to 20% of children. Indicators, such as a specific protein level in the body which is related to the presence or seriousness of a disease in a patient, may be important in ensuring proper treatment. Indicators of the seriousness of AD have been described for adults, however there is a need for similar indicators which could be used to define the seriousness of AD in infants, as this is usually when onset of the condition occurs. This study aimed to identify easily obtainable indicators from the skin of infants which could be used to predict AD. 100 children who had just developed moderate to severe AD which had not yet been treated and 20 children without AD were sampled as part of this study. The level of seriousness of AD in the affected children was graded at the start of the study and samples of the outer‐most layer of skin were taken from all participants. In total, 31 out of 66 indicators measured showed different levels in infants with AD than infants without AD. These indicators are known to be involved in various processes including the body's natural defence and the formation of new blood vessels. The authors of this study concluded that these results demonstrate easily obtainable indicators can be used to predict AD in infants, and that natural defence responses in the outer layer of skin are essential in preventing development of AD in infants.