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Image Gallery: Minocycline‐induced photo‐onycholysis with pigmentation
Author(s) -
McCarthy S.,
Bourke J.F.
Publication year - 2019
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.17417
Subject(s) - onycholysis , minocycline , dermatology , medicine , pigmentation disorder , ophthalmology , paronychia , biology , antibiotics , microbiology and biotechnology
DEAR EDITOR, A 23-year-old male patient was treated with minocycline 100 mg daily for folliculitis. After 3 months, crescent-shaped onycholysis of the lateral nail bed of the fingernails with secondary brown pigmentation, sparing the thumbs, was noted (a). The lunula, distal nail plate and toenails were unaffected. The onycholysis and pigmentation had fully resolved on review 6 months after cessation of minocycline (b). Drug-induced photo-onycholysis is rare, affects several fingers and usually spares the thumbs. The drugs most commonly implicated are tetracyclines and psoralens. Blue-grey or brown pigmentation can also occur with tetracycline therapy, but nail involvement is rare.