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Prospective, randomized, double‐blind assessment of topical bakuchiol and retinol for facial photoageing
Author(s) -
Dhaliwal S.,
Rybak I.,
Ellis S.R.,
Notay M.,
Trivedi M.,
Burney W.,
Vaughn A.R.,
Nguyen M.,
Reiter P.,
Bosanac S.,
Yan H.,
Foolad N.,
Sivamani R.K.
Publication year - 2019
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.16918
Subject(s) - medicine , tolerability , dermatology , retinol , randomized controlled trial , ophthalmology , pharmacology , adverse effect , vitamin
Summary Background Bakuchiol is a phytochemical that has demonstrated cutaneous antiageing effects when applied topically. Early studies have suggested that bakuchiol is a functional analogue of topical retinoids, as both compounds have been shown to induce similar gene expression in the skin and lead to improvement of cutaneous photodamage. No in vivo studies have compared the two compounds for efficacy and side‐effects. Objectives To compare the clinical efficacy and side‐effect profiles of bakuchiol and retinol in improving common signs of cutaneous facial ageing. Methods This was a randomized, double‐blind, 12‐week study in which 44 patients were asked to apply either bakuchiol 0·5% cream twice daily or retinol 0·5% cream daily. A facial photograph and analytical system was used to obtain and analyse high‐resolution photographs of patients at 0, 4, 8 and 12 weeks. Patients also completed tolerability assessment questions to review side‐effects. During study visits, a board‐certified dermatologist, blinded to study group assignments, graded pigmentation and redness. Results Bakuchiol and retinol both significantly decreased wrinkle surface area and hyperpigmentation, with no statistical difference between the compounds. The retinol users reported more facial skin scaling and stinging. Conclusions Our study demonstrates that bakuchiol is comparable with retinol in its ability to improve photoageing and is better tolerated than retinol. Bakuchiol is promising as a more tolerable alternative to retinol.