Merkel cell polyomavirus is uncommon in New Zealand Merkel cell carcinomas | Zendy

Woodhouse B. | Zendy; Robb T.J. | Zendy; Hearn J.I. | Zendy; Houseman P.S. | Zendy; Hayward G. | Zendy; Miller R. | Zendy; Restall A.P. | Zendy; Findlay M. | Zendy; Lawrence B. | Zendy; Print C.G. | Zendy; Parker K. | Zendy; Blenkiron C. | Zendy

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Merkel cell polyomavirus is uncommon in New Zealand Merkel cell carcinomas

Author(s) -

Woodhouse B.,

Robb T.J.,

Hearn J.I.,

Houseman P.S.,

Hayward G.,

Miller R.,

Restall A.P.,

Findlay M.,

Lawrence B.,

Print C.G.,

Parker K.,

Blenkiron C.

Publication year - 2018

Publication title -

british journal of dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.304

H-Index - 179

eISSN - 1365-2133

pISSN - 0007-0963

DOI - 10.1111/bjd.16903

Subject(s) - merkel cell polyomavirus , merkel cell , merkel cell carcinoma , polyomavirus infections , dermatology , cell , medicine , pathology , cell of origin , biology , carcinoma , genetics , kidney , bk virus , kidney transplantation

Merkel Cell Carcinoma (MCC) is a rare skin tumour with an incidence of 0.88 per 100,000 people in New Zealand (NZ), one of the highest in the world1 and almost on par with close neighbours Australia2 . Current local diagnostic guidelines do not require analysis of the oncogenic Merkel Cell Polyoma Virus (MCPyV), therefore it has never been questioned whether the NZ-MCC MCPyV rate is similar to North American and European studies (40-89%) or indeed lower, as reported in Australian cohorts (18-24%) in which a UV-mediated etiology is dominant3-5 . To investigate the presence of the MCPyV in NZ-MCCs we established droplet digital PCR (ddPCR, Bio-Rad) assays to amplify viral gene LTA6 and gene expression of LTA, in parallel with a viral protein immunohistochemistry (IHC) assay using the commercial CM2B4 antibody4 . This article is protected by copyright. All rights reserved.

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