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Effects of treatment for psoriasis on circulating levels of leptin, adiponectin and resistin: a systematic review and meta‐analysis
Author(s) -
Kyriakou A.,
Patsatsi A.,
Sotiriadis D.,
Goulis D.G.
Publication year - 2018
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.16437
Subject(s) - resistin , adiponectin , medicine , adipokine , leptin , psoriasis , meta analysis , endocrinology , population , confidence interval , metabolic syndrome , gastroenterology , obesity , immunology , insulin resistance , environmental health
Summary Background Metabolic syndrome, a risk factor of cardiovascular disease, is more common in patients with psoriasis than in the general population. Circulating adipokine concentrations are altered in patients with psoriasis and are suggested to represent the pathophysiological link between psoriatic lesions and metabolic alterations. Objectives To perform a systematic review of the literature for studies that investigated possible differences in circulating levels of leptin, adiponectin or resistin in patients with psoriasis before and after any treatment intervention, and to meta‐analyse the best evidence available. Methods A search was conducted in three databases (PubMed, Central and Embase). Eligible for the review were studies that assessed leptin, adiponectin or resistin concentrations in patients with psoriasis before and after any topical or systemic treatment. Results After treatment, blood concentrations of leptin were similar to those before treatment [standardized mean difference ( SMD ) 0·06, 95% confidence interval ( CI ) −0·09 to 0·20], with no heterogeneity among studies ( I 2 = 0%, P = 0·88). After treatment, blood concentrations of adiponectin were similar to those before treatment ( SMD −0·14, 95% CI −0·34 to 0·05), with significant heterogeneity among studies ( I 2 = 36·8%, P = 0·032). After treatment, blood concentrations of resistin were significantly lower than those before treatment ( SMD 0·50, 95% CI 0·20–0·79), with significant heterogeneity among studies ( I 2 = 61·4%, P < 0·001). Conclusions There is no evidence that treatment for psoriasis modifies leptin and adiponectin concentrations. However, treatment intervention reduces resistin concentrations, a finding that is expected to be of clinical importance.