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Risk prediction tools for keratinocyte carcinoma after solid organ transplantation: a review of the literature
Author(s) -
Lowenstein S.E.,
Garrett G.,
Toland A.E.,
JambusariaPahlajani A.,
Asgari M.M.,
Green A.,
Engels E.A.,
Arron S.T.
Publication year - 2017
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.15889
Subject(s) - basal cell carcinoma , immunosuppression , medicine , malignancy , skin cancer , keratinocyte , basal cell , population , transplantation , organ transplantation , dermatology , oncology , carcinoma , pathology , cancer , biology , cell culture , environmental health , genetics
Summary Long‐term iatrogenic immunosuppression increases the risk of cutaneous malignancies in organ transplant recipients ( OTR s), particularly the keratinocyte cancers basal cell carcinoma and cutaneous squamous cell carcinoma ( cSCC ). cSCC is the most common malignancy in OTR s, with the risk increased to over 65‐fold in transplanted patients relative to the general population. There have been very few risk prediction tools developed for accurate determination of the risk of developing keratinocyte cancers in the OTR population. This review summarizes the prediction tools developed to date, and outlines future directions for developing more accurate prediction models that are clinically useful for the transplant physician and dermatologist.