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A genome‐wide association study suggests that MAPK 14 is associated with diabetic foot ulcers
Author(s) -
Meng W.,
Veluchamy A.,
Hébert H.L.,
Campbell A.,
Colhoun H.M.,
Palmer C.N.A.
Publication year - 2017
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.15787
Subject(s) - medicine , type 2 diabetes , diabetes mellitus , peripheral neuropathy , foot (prosody) , diabetic foot , cohort , genome wide association study , type 1 diabetes , single nucleotide polymorphism , genetics , biology , endocrinology , genotype , gene , philosophy , linguistics
Summary Background Diabetic foot ulcers ( DFU s) are a devastating complication of diabetes. Objectives To identify genetic contributors to the development of DFU s in the presence of peripheral neuropathy in a Scottish cohort with diabetes using a genome‐wide association study. Methods A genome‐wide association approach was applied. A case was defined as a person with diabetes (type 1 or type 2) who had ever had a foot ulcer (current or previous) in at least one foot, as well as a positive monofilament test result (i.e. evidence of peripheral neuropathy) recorded in their longitudinal e‐health records. A control was defined as an individual with diabetes (type 1 or type 2) who has never been recorded as having a foot ulcer in either foot but who had a positive monofilament test result recorded in either foot in their longitudinal e‐health records. Results There were 699 DFU cases and 2695 controls in the Genetics of Diabetes Audit and Research in Tayside Scotland (Go DARTS ) dataset. The single‐nucleotide polymorphism rs80028505 (Chr6p21·31) in MAPK 14 reached genome‐wide significance with a lowest P ‐value of 2·45 × 10 −8 . The narrow‐sense heritability of this phenotype is 0·06. Conclusions We suggest that MAPK 14 is associated with DFU s.