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Invasive dermatophyte infection with Trichophyton interdigitale is associated with prurigo‐induced pseudoperforation and a signal transducer and activator of transcription 3 mutation
Author(s) -
Simpson J.K.,
Fröbel P.,
Seneviratne S.L.,
Brown M.,
Lowe D.M.,
Grimbacher B.,
Fliegauf M.,
Fearfield L.
Publication year - 2018
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.15781
Subject(s) - dermatophyte , stat protein , trichophyton , medicine , transcription (linguistics) , dermatology , biology , genetics , gene , stat3 , antifungal , linguistics , philosophy
Summary Invasive dermatophyte infection, with extension beyond the dermis, in immunocompetent hosts is exceptionally rare. Dermatophytes are keratinophilic and are usually confined to the stratum corneum, hair and nails. Susceptibility to dermatophyte infections is incompletely understood, but inherited mutations in key signalling pathways of the innate immune system have been identified. We report the first case of an invasive dermatophyte infection associated with abrupt onset of a prurigo‐induced pseudoperforation and a loss‐of‐function mutation in signal transducer and activator of transcription 3 ( STAT 3).