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Sustained Psoriasis Area and Severity Index, Dermatology Life Quality Index and EuroQol‐5D response of biological treatment in psoriasis: 10 years of real‐world data in the Swedish National Psoriasis Register
Author(s) -
Hjalte F.,
Carlsson K.S.,
SchmittEgenolf M.
Publication year - 2018
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.15757
Subject(s) - dermatology life quality index , psoriasis , psoriasis area and severity index , medicine , observational study , quality of life (healthcare) , eq 5d , severity of illness , dermatology , health related quality of life , disease , nursing
Summary Background Few studies have analysed the long‐term effects of biological treatment in psoriasis. PsoReg, the Swedish national register for systemic psoriasis treatment, started in 2006 and now includes 10 years of real‐world data on the effectiveness of biological treatment. Objectives To analyse the long‐term real‐world outcome data of patients who are biologically naïve with moderate‐to‐severe psoriasis after switching to biological treatment. Methods An observational study of patients who are biologically naïve with at least one registration of outcome before switching to biological treatment while included in PsoReg and at least one follow‐up visit. Psoriasis Area and Severity Index ( PASI ), Dermatology Life Quality Index ( DLQI ) and EuroQol‐5D ( EQ ‐5D) values were analysed at 3–5 months, 6–11 months and at least once after ≥ 1 year, up to 9 years after the switch to biological treatment. Results In total, 583 patients fulfilled the inclusion criteria. Of these, 399, 395 and 373 patients had observed outcome data beyond 1 year on the PASI , DLQI and EQ ‐5D, respectively, and 164, 168 and 152, respectively, were observed in at least three time periods after the switch. Significant (P < 0·01) improvement in PASI , DLQI and EQ ‐5D scores was observed 3–5 months after the switch and sustained under the whole observation period. The mean PASI , DLQI and EQ ‐5D changed from 13·5 ± 9·1, 9·0 ± 8·1 and 0·74 ± 0·22, respectively, before the switch, to 4·0 ± 3·5, 3·7 ± 4·7 and 0·79 ± 0·21, respectively, 1–5 years after the switch. Conclusions Biological treatment, as used in clinical practice, shows a stable long‐term effectiveness in all the measured dimensions, PASI , DLQI and EQ ‐5D.