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A systematic review of pharmacogenetic studies on the response to biologics in patients with psoriasis
Author(s) -
van Vugt L.J.,
van den Reek J.M.P.A.,
Coenen M.J.H.,
de Jong E.M.G.J.
Publication year - 2018
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.15753
Subject(s) - ustekinumab , pharmacogenetics , psoriasis , medicine , cochrane library , adalimumab , medline , personalized medicine , meta analysis , oncology , bioinformatics , dermatology , genetics , gene , tumor necrosis factor alpha , genotype , biology , biochemistry
Summary Background Biologics are indicated for treating moderate‐to‐severe psoriasis. As the number of biologics registered for the treatment of psoriasis increases, so does the need for biomarkers to guide personalized therapeutic decisions. Genetic variants might serve as predictors for treatment response, a field of research known as pharmacogenetics. Objectives To assess which genetic variants are associated with response to biologics in patients with psoriasis according to current literature. Methods A systematic search was performed in Embase, MEDLINE , the Cochrane Library and Web of Science. In total, 26 papers were included in this systematic review; 24 original studies and two meta‐analyses. Quality was assessed using a predesigned form and risk of bias was assessed using the Newcastle–Ottawa Scale. Results The majority of studies reported a candidate gene approach, focusing on polymorphisms in genes related to the therapeutic target or to psoriasis susceptibility. Studied populations were small and results were divergent, especially for studies investigating tumour necrosis factor inhibitors. The evidence for the role of HLA ‐ Cw6 in ustekinumab efficacy shows minimal heterogeneity, with a higher response rate among patients who were positive for HLA ‐Cw6 reported across three of five studies. Conclusions Pharmacogenetic studies in psoriasis have generated divergent results. Replication of findings in larger cohorts is required. Large‐scale hypothesis‐free searches for genetic biomarkers are needed to uncover the complete genetic background of outcomes for treatment with biologics.