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Variants at the OCA 2 / HERC 2 locus affect time to first cutaneous squamous cell carcinoma in solid organ transplant recipients collected using two different study designs
Author(s) -
Wei L.,
Allain D.C.,
Bernhardt M.N.,
Gillespie J.L.,
Peters S.B.,
Iwenofu O.H.,
Nelson H.H.,
Arron S.T.,
Toland A.E.
Publication year - 2017
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.15618
Subject(s) - organ transplantation , hazard ratio , locus (genetics) , skin cancer , allele , genotyping , medicine , oncology , biology , genetics , transplantation , cancer , genotype , confidence interval , gene
Summary Background Variants at the oculocutaneous albinism 2 ( OCA 2 )/ HECT and RLD domain containing E3 ubiquitin protein ligase 2 ( HERC 2 ) locus have been associated with pigmentation phenotypes and risk of developing several types of skin cancer. Objectives To evaluate OCA 2 / HERC 2 locus variants for their impact on time to develop cutaneous squamous cell carcinoma ( cSCC ) in organ transplant recipients ( OTR s) who are at elevated risk of developing cSCC . Methods Participants were solid OTR s ascertained from two centres ( n = 125 and 261) with an average of 13·1 years of follow‐up post‐transplant. DNA was available for genotyping for all participants, in addition to medical records and questionnaire data. The Ohio State University study had a case–control design with prospective follow‐up, and the University of California San Francisco study was a national cross‐sectional survey with retrospective chart review. Results OCA 2 variants rs12913832 and rs916977 were significantly associated with time to first cSCC post‐transplant. OTR s homozygous for the brown‐eye alleles of rs916977 ( GG ) and rs12913832 ( AA ) had significant delays of time to first cSCC post‐transplant compared with individuals homozygous for the blue‐eye alleles (hazard ratio 0·34, P < 0·001 and hazard ratio 0·54, P = 0·012, respectively). Both variants were highly associated with eye colour in the combined studies ( P < 0·001). Conclusions This study is the first to show an association between OCA 2 / HERC 2 variants and time to first cSCC post‐transplant. This may impact dermatological screening recommendations for high‐risk populations.