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The pathogenesis of dermatomyositis
Author(s) -
Thompson C.,
Piguet V.,
Choy E.
Publication year - 2018
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.15607
Subject(s) - dermatomyositis , pathogenesis , immunology , autoantibody , medicine , pathology , antibody
Summary This review looks at the many different factors thought to play a role in idiopathic inflammatory myopathies ( IIM ), concentrating mainly on the dermatomyositis ( DM ) subtype. Subject areas addressed include looking at the different clinical features of IIM , paying particular attention to the skin manifestations. There is a discussion around investigations needed with their perceived value, followed by a description of the immunohistochemical findings of DM . This review goes on to address other attributing factors such as genetic associations with the different subtypes of IIM , and environmental factors including infections, ultraviolet radiation and vitamin D deficiency and drugs. Finally, the potential immunopathogenesis of DM is summarized, looking at T cells, B cells, autoantibodies, dendritic cells, cytokines and nonimmune‐mediated endoplasmic reticulum stress.