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Autologous cell suspension grafting in segmental vitiligo and piebaldism: a randomized controlled trial comparing full surface and fractional CO 2 laser recipient‐site preparations
Author(s) -
Lommerts J.E.,
Meesters A.A.,
Komen L.,
Bekkenk M.W.,
Rie M.A.,
Luiten R.M.,
Wolkerstorfer A.
Publication year - 2017
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.15569
Subject(s) - vitiligo , medicine , ablation , transplantation , randomized controlled trial , surgery , suspension culture , dermatology , cell culture , biology , genetics
Summary Background Autologous noncultured cell suspension transplantation is an effective treatment for repigmentation in segmental vitiligo and piebaldism. Full surface laser ablation is frequently used to prepare the recipient site before cell suspension transplantation, even though the optimal laser settings and ablation depth are unknown. Objectives To assess the efficacy and safety of less invasive recipient‐site preparations. Methods In a randomized, observer‐blinded, controlled trial we compared different recipient‐site preparations before cell suspension transplantation in segmental vitiligo and piebaldism. In each patient, we randomly allocated three CO 2 laser recipient‐site preparations (209 and 144 μm full surface, and fractional) and a control (no treatment) to four depigmentations. After 6 months we assessed repigmentation and side‐effects. Results We included 10 patients with vitiligo ( n = 3) and piebaldism ( n = 7). Compared with the control site, we found more repigmentation after full surface ablation at 209 μm (median 68·7%, P = 0·01) and 144 μm (median 58·3%, P = 0·007), but no repigmentation after fractional ablation (median 0·0%, P = 0·14). Conclusions Superficial full surface ablation with a depth of 144 μm is an effective recipient‐site preparation before cell suspension transplantation, while fractional CO 2 laser is not.