Premium
Ultrastructural characterization of hyperactive endothelial cells, pericytes and fibroblasts in hypertrophic and nodular port‐wine stain lesions
Author(s) -
Gao L.,
Yin R.,
Wang H.,
Guo W.,
Song W.,
Nelson J.S.,
Tan W.,
Wang G.
Publication year - 2017
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.15373
Subject(s) - pathology , ultrastructure , stain , port wine stain , pathogenesis , medicine , pathological , anatomy , staining , laser , physics , optics
Author(s): Gao, L; Yin, R; Wang, H; Guo, W; Song, W; Nelson, JS; Tan, W; Wang, G | Abstract: Port wine stain (PWS) is a congenital vascular malformation of human skin involving the superficial vascular plexus,1-4 but the molecular pathogenesis of these lesions remains incompletely understood.5-8 We herein performed a transmission electron microscopy (TEM) study to determine the main pathological characteristics and ultrastructure of various cell types, including endothelial cells (ECs), pericytes, fibroblasts and keratinocytes, in hypertrophic and nodular PWS. The study was approved by the Investigational Review Board at the Xijing Hospital, Xi'an, China. This article is protected by copyright. All rights reserved.