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Patient‐Oriented Eczema Measure ( POEM ), a core instrument to measure symptoms in clinical trials: a Harmonising Outcome Measures for Eczema ( HOME ) statement
Author(s) -
Spuls P.I.,
Gerbens L.A.A.,
Simpson E.,
Apfelbacher C.J.,
Chalmers J.R.,
Thomas K.S.,
Prinsen C.A.C.,
Kobyletzki L.B.,
Singh J.A.,
Williams H.C.,
Schmitt J.
Publication year - 2017
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.15179
Subject(s) - medicine , clinical trial , quality of life (healthcare) , medline , reliability (semiconductor) , core (optical fiber) , measure (data warehouse) , outcome (game theory) , randomized controlled trial , physical therapy , family medicine , medical physics , pediatrics , surgery , nursing , pathology , computer science , data mining , telecommunications , power (physics) , physics , mathematics , mathematical economics , quantum mechanics , political science , law
Summary Background The Harmonising Outcome Measures for Eczema ( HOME ) initiative has defined four core outcome domains for a core outcome set ( COS ) to be measured in all atopic eczema ( AE ) trials to ensure cross‐trial comparison: clinical signs, symptoms, quality of life and long‐term control. Objectives The aim of this paper is to report on the consensus process that was used to select the core instrument to consistently assess symptoms in all future AE trials. Methods Following the HOME roadmap, two systematic reviews were performed which identified three instruments that had sufficient evidence of validity, reliability and feasibility to be considered for the final COS . Results At the fourth international HOME meeting, there was broad consensus among all stakeholders that the Patient‐Oriented Eczema Measure ( POEM ) should be used as the core instrument (87·5% agreed, 9·4% unsure, 3·1% disagreed). Conclusions All relevant stakeholders are encouraged to use POEM as the chosen instrument to measure the core domain of symptoms in all future AE clinical trials. Other instruments of interest can be used in addition to POEM .