Patient‐Oriented Eczema Measure ( POEM ), a core instrument to measure symptoms in clinical trials: a Harmonising Outcome Measures for Eczema ( HOME ) statement | Zendy

Spuls P.I. | Zendy; Gerbens L.A.A. | Zendy; Simpson E. | Zendy; Apfelbacher C.J. | Zendy; Chalmers J.R. | Zendy; Thomas K.S. | Zendy; Prinsen C.A.C. | Zendy; Kobyletzki L.B. | Zendy; Singh J.A. | Zendy; Williams H.C. | Zendy; Schmitt J. | Zendy

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Patient‐Oriented Eczema Measure ( POEM ), a core instrument to measure symptoms in clinical trials: a Harmonising Outcome Measures for Eczema ( HOME ) statement

Author(s) -

Spuls P.I.,

Gerbens L.A.A.,

Simpson E.,

Apfelbacher C.J.,

Chalmers J.R.,

Thomas K.S.,

Prinsen C.A.C.,

Kobyletzki L.B.,

Singh J.A.,

Williams H.C.,

Schmitt J.

Publication year - 2017

Publication title -

british journal of dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.304

H-Index - 179

eISSN - 1365-2133

pISSN - 0007-0963

DOI - 10.1111/bjd.15179

Subject(s) - medicine , clinical trial , quality of life (healthcare) , core (optical fiber) , measure (data warehouse) , outcome (game theory) , patient reported outcome , set (abstract data type) , physical therapy , family medicine , pediatrics , nursing , pathology , data mining , computer science , telecommunications , mathematics , mathematical economics , programming language

Summary Background The Harmonising Outcome Measures for Eczema ( HOME ) initiative has defined four core outcome domains for a core outcome set ( COS ) to be measured in all atopic eczema ( AE ) trials to ensure cross‐trial comparison: clinical signs, symptoms, quality of life and long‐term control. Objectives The aim of this paper is to report on the consensus process that was used to select the core instrument to consistently assess symptoms in all future AE trials. Methods Following the HOME roadmap, two systematic reviews were performed which identified three instruments that had sufficient evidence of validity, reliability and feasibility to be considered for the final COS . Results At the fourth international HOME meeting, there was broad consensus among all stakeholders that the Patient‐Oriented Eczema Measure ( POEM ) should be used as the core instrument (87·5% agreed, 9·4% unsure, 3·1% disagreed). Conclusions All relevant stakeholders are encouraged to use POEM as the chosen instrument to measure the core domain of symptoms in all future AE clinical trials. Other instruments of interest can be used in addition to POEM .

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