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Two cases of overlap severe cutaneous adverse reactions to benznidazole treatment for asymptomatic Chagas disease in a nonendemic country
Author(s) -
GonzálezRamos J.,
NogueraMorel L.,
Tong H.Y.,
Ramírez E.,
RuizBravo E.,
Bellón T.,
Cabañas R.,
Cachafeiro L.,
HerranzPinto P.
Publication year - 2016
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.14451
Subject(s) - benznidazole , medicine , asymptomatic , chagas disease , disease , dermatology , adverse effect , immunology , trypanosoma cruzi , parasite hosting , world wide web , computer science
Summary Chagas disease is a parasitosis endemic to South America. It is normally treated with benznidazole as first choice, which has been associated with numerous cutaneous reactions. However, very few benznidazole‐associated severe cutaneous adverse reactions have been reported to date. The rise of Chagas disease in nonendemic countries represents a growing public health challenge. We report two patients who met the criteria for drug reaction with eosinophilia and systemic symptoms syndrome and Stevens–Johnson syndrome/toxic epidermal necrolysis according to the Regi SCAR scoring systems. They were thus deemed overlapping cases, with a lymphocyte transformation test positive for benznidazole. Both required intensive care unit admission and both survived. Considering the rising application of this drug for trypanosomiasis in immigrant populations, clinicians should be aware of this newly reported, potentially life‐threatening risk.