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Continuous usage of a hair dye product containing 2‐methoxymethyl‐ para ‐phenylenediamine by hair‐dye‐allergic individuals
Author(s) -
Kock M.,
Coenraads P.J.,
Blömeke B.,
Goebel C.
Publication year - 2016
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.14390
Subject(s) - hair dyes , p phenylenediamine , dermatology , product (mathematics) , chemistry , medicine , organic chemistry , mathematics , dyeing , geometry
Summary Background Despite a positive patch test reaction to para ‐phenylenediamine ( PPD ) and/or toluene‐2,5‐diamine ( PTD ), many people attempt to continue dyeing their hair with products containing PPD or its derivatives. Objectives Investigation of elicitation reactions among PPD / PTD ‐allergic individuals to hair dye products containing the less sensitizing PPD derivative 2‐methoxymethyl ( ME )‐ PPD . Methods Elicitation reactions were studied in 43 PPD / PTD ‐allergic individuals by a 45‐min pretest with an ME ‐ PPD ‐containing hair dye on their forearm. Upon a negative result this was followed by exposure to subsequent hair colour treatment(s). Results Overall, 38 of 43 PPD / PTD ‐allergic individuals did not develop an elicitation reaction during the pretest with ME ‐ PPD ‐containing hair dye products, and were eligible for subsequent hair colour treatments. Of these 38 PPD / PTD ‐allergic individuals, 29 tolerated subsequent hair dyeing with ME ‐ PPD ‐containing hair dye products, while seven showed mild and two showed moderate/marked allergic reactions upon the first hair colour treatment. Conclusions Hair dye products with the less sensitizing ME ‐ PPD were tolerated by 29 of 43 (67%) PPD / PTD ‐allergic individuals throughout continued hair dyeing with an average of nine treatments per year. Five individuals reacted upon pretesting, while only mild‐to‐moderate/marked skin reactions occurred upon hair dyeing in nine individuals who were not identified by the pretest. To our knowledge this is the first study among PPD / PTD ‐allergic individuals indicating that a negative 45‐min pretest with a hair dye product helps to avoid severe allergic reactions.