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Alitretinoin: treatment for refractory palmoplantar keratoderma
Author(s) -
Park H.K.,
Kim E.J.,
Ko J.Y.
Publication year - 2016
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.14327
Subject(s) - dermatology , medicine , family medicine
Mal de Meleda (MDM) is an autosomal recessive form of palmoplantar keratoderma caused by mutations in the ARS gene, encoding SLURP-1.(1) It has been reported that etretinate and acitretin, which are aromatic retinoids, are effective treatment modalities for MDM.(2) However, early and long-term use of these retinoids are associated with several well-known adverse effects, such as dryness, teratogenicity and liver toxicity. This article is protected by copyright. All rights reserved.