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Paediatric necrolytic migratory erythema as a presenting sign of glucagonoma syndrome
Author(s) -
Luber A.J.,
Ackerman L.S.,
Culpepper K.S.,
Buschmann C.M.,
Koep L.J.
Publication year - 2016
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.14298
Subject(s) - glucagonoma , rash , medicine , dermatology , erythema , pathology , pancreas , insulinoma
Summary Glucagonoma syndrome is an extremely rare pancreatic neuroendocrine tumour often associated with necrolytic migratory erythema. While glucagonomas are neoplasms of adulthood, we report the first case in a paediatric patient. We present the case of a 15‐year‐old girl with a 4‐year history of a rash, consistent with necrolytic migratory erythema, found to have a localized glucagonoma. Immediately following resection of the tumour, there was complete resolution of her rash and systemic symptoms. Detection of the cutaneous rash of necrolytic migratory erythema can aid in the early diagnosis of a glucagonoma, as well as the prevention of metastatic disease. To our knowledge, this is the first reported paediatric patient with glucagonoma syndrome.