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Concomitant neoplasms in the skin and stomach unveil the role of type IV collagen and E‐cadherin in mucin core protein 5 AC expression in vivo
Author(s) -
Hata H.,
Natsuga K.,
Kitamura S.,
Imafuku K.,
Yamaguchi Y.,
Ebihara Y.,
Shichinohe T.,
Hirano S.,
Shimizu H.
Publication year - 2016
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.14084
Subject(s) - mucin , cadherin , in vivo , pathology , concomitant , stomach , cancer , extracellular matrix , medicine , chemistry , biology , microbiology and biotechnology , cell , biochemistry , genetics
Summary Mucin core protein ( MUC ) 5 AC is a gel‐forming glycoprotein that is expressed in different types of tumour cells. MUC 5 AC expression in cultured cells is regulated through the extracellular matrix and through remodelling by other membranous proteins such as type IV collagen ( COL 4) and E‐cadherin. However, it has not been elucidated whether COL 4 and E‐cadherin affect MUC 5 AC expression in tumours in vivo . Here, by analysing a single individual with concomitant neoplasms in the skin [extramammary Paget disease ( EMPD )] and the stomach (gastric cancer), we show that MUC 5 AC expression is reduced in COL 4 and membranous E‐cadherin‐expressing EMPD specimens whereas MUC 5 AC is not abolished in gastric cancer with COL 4 negativity and E‐cadherin cytoplasmic localization. As the EMPD and gastric cancer specimens were derived from a single patient, each specimen had the same genetic background. These in vivo results support previous in vitro studies which showed that COL 4 and E‐cadherin downregulated MUC 5 AC expression. Our study suggests that concomitant neoplasms in different organs of the same individual can serve as a strong tool for uncovering functional diversity in tumour markers in distinct cancer cells.