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Merkel cell carcinoma in a patient with GATA 2 deficiency: a novel association with primary immunodeficiency
Author(s) -
Crall C.,
Morley K.W.,
Rabinowits G.,
Schmidt B.,
Broyles A. Dioun,
Huang J.T.
Publication year - 2016
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.14062
Subject(s) - merkel cell carcinoma , primary immunodeficiency , immunodeficiency , immunosuppression , neurofibromatosis , medicine , merkel cell polyomavirus , immunologic deficiency syndromes , malignancy , immunology , dermatology , carcinoma , pathology , immune system
Summary A 55‐year‐old woman with GATA 2 deficiency and neurofibromatosis 1 was diagnosed with Merkel cell carcinoma ( MCC ). This polyomavirus‐associated cutaneous malignancy has previously been associated with immunosuppression and acquired immunodeficiencies such as HIV / AIDS . However, MCC has not been previously reported in the setting of underlying primary or inherited immunodeficiency.