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Increased expression of interleukin‐17 pathway genes in nonlesional skin of moderate‐to‐severe psoriasis vulgaris
Author(s) -
Chiricozzi A.,
SuárezFariñas M.,
FuentesDuculan J.,
Cueto I.,
Li K.,
Tian S.,
Brodmerkel C.,
Krueger J.G.
Publication year - 2016
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.14034
Subject(s) - psoriasis , immune system , cd8 , biology , immunology , gene expression , transcriptome , gene , interleukin , pathology , cytokine , medicine , genetics
Summary Background Psoriasis vulgaris is an inflammatory immune‐mediated disease, with lesional skin characterized by sharply demarcated, erythematous scaly plaques. Uninvolved psoriatic skin appears clinically similar to normal skin. However, it has been hypothesized that inflammatory cytokines, e.g. interleukin ( IL )‐17, may affect any organ or tissue having a vascular supply; thus, distant uninvolved skin could be exposed to increased circulating IL ‐17. Objectives To establish comparative genomic profiles between noninvolved skin and normal skin, in particular, determining immune abnormalities in distant uninvolved skin. Methods We performed a meta‐analysis on three gene array studies, comparing the nonlesional ( NL ) psoriatic skin transcriptome with normal gene expression. We investigated immunological features of noninvolved skin, particularly linked to IL ‐17 signalling. Results We detected 252 differentially expressed gene transcripts in uninvolved skin compared with normal skin; multiple immune‐related genes, including IL ‐17‐downstream genes, were upregulated. Increased expression of IL ‐17‐signature genes (e.g. DEFB 4 and S100A7 ) was associated with an increased number of CD3+, CD8+ and DC‐LAMP+ cells in NL skin vs. normal controls. Inducible T‐cell costimulator ( ICOS ) expression was detected only in a few T‐cells within NL skin. Conclusions Our data described the genomic profile in NL skin, characterizing the immune activation that was mainly attributed to IL ‐17 signalling.